Breakthroughs Blog

Breakthroughs brings you stories of bright ideas and bold innovations in global health.

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Ansley Kahn
Research Roundup: Thyme oil and corn starch used as larvicide, Gates Foundation grants for a universal flu vaccine, and Gavi calls on donors

In this regular feature on Breakthroughs, we highlight some of the most interesting reads in global health research from the past week.

Recent

Research Roundup: genetic protection against malaria, the vaccine pipeline, and counterfeit drugs and the FDA

A new study conducted by the Malaria Genomic Epidemiology Network (MalariaGEN)—a community of researchers across malaria-endemic regions—reveals a formerly unknown genetic variations that make people less susceptible to malaria.

GHTC
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PATH/Evelyn Hockstin
Research Roundup: a promising Ebola treatment, access to drugs for NCDs, a new approach to treating a deadly bacterium, and the perception of breakthrough drugs

The US Department of Health and Human Services (HHS) is partnering with New York–based Regeneron Pharmaceuticals, Inc. for the development of an Ebola treatment.

GHTC
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PATH/James Gathaney
Research Roundup: antibiotic and reproductive health R&D, leadership at the FDA, and a potential new strain of dengue fever.

The US Department of Health and Human Services (HHS) announced last week a partnership with pharmaceutical company AstraZeneca for the research and development (R&D) of antibiotics.

GHTC
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PATH/Patrick McKern
Female condoms: the feel and shape of things to come

Take a stroll through any pharmacy and you’ll see shelves stacked with male condoms of many varieties, but look for a female condom and you aren't likely to find one for sale.

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Advocacy and partnerships for HIV/AIDS prevention for women: A post from Durban, South Africa

Sitting halfway around the world from my office in Washington, DC, looking out my Durban hotel window at the Indian Ocean, I am reminded just how small and interconnected our world really is.

GHTC
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Research Roundup: HIV/AIDS self-testing and advances in dengue fever and sleeping sickness R&D

A new study suggests that with basic training, individuals can learn to accurately and safely test themselves for HIV/AIDS.

GHTC
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To meet the global goals, UN must include health R&D indicators in SDG framework

Later this month global leaders are poised to approve the Sustainable Development Goals (SDGs), but a new report commissioned by a leading group of health nonprofits including GHTC warns that the SDG targets will not be achieved without the development and introduction of new and improved health technologies to address the health needs of the world’s poorest people.

GHTC
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PATH/Eric Becker
Research Roundup: injectable HIV treatment, the role of health technologies in reaching SDGs, PrEP showing promise, and more

An injectable HIV/AIDS treatment that could offer HIV-positive individuals an option other than taking daily pills is entering late-stage clinical-trials.

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Pipeline report points toward nascent progress in the fight against tuberculosis

In this guest post, Lindsay McKenna, TB/HIV project officer at GHTC member Treatment Action Group (TAG), writes about a newly released report examining advancements in tuberculosis (TB) research and development (R&D).

Treatment Action Group
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PATH/Aaron Joel Santos
Research Roundup: priority review vouchers, diagnosing drug resistance, and oral and universal flu vaccines

Pharmaceutical company AbbVie is paying United Therapeutics US$350 million for its priority review voucher (PRV)—which expedites the US Food and Drug Administration’s (FDA) review of a product by four months—and EP Vantage speculates on their motive.

GHTC
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Research Roundup: a rapid diagnostic for three hemorrhagic fevers, a MERS vaccine to be tested in humans, and advances in R&D for HIV treatments

A new paper-based diagnostic can test for Ebola, dengue, and yellow fever in just ten minutes without running water, electricity, lab equipment, or highly-trained personnel.

GHTC
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Research Roundup: combatting malaria with forensics, detecting counterfeit drugs out of a suitcase, and preventing the flu without a vaccine

Luminol has long been used to detect blood at crime scenes, as it glows bright blue when it comes into contact with the blood protein hemoglobin, however, new research suggests that it could be repurposed to fight malaria in humans.

GHTC
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The latest in MERS R&D: Do we have the tools needed to prevent the next outbreak?

Since its discovery in 2012, cases of Middle East Respiratory Syndrome (MERS)—a disease World Health Organization (WHO) Director-General Dr. Margaret Chan called “a threat to the entire world”— have been reported in 27 countries across four continents.

GHTC
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Research Roundup: 3D-printed drugs, R&D in emergency settings, a universal flu vaccine, and more

The US Food and Drug Administration (FDA) approved the first 3D-printed drug last week, paving the way for the technology to be used to customize medical care to individual patients.

GHTC
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When breastfeeding is not possible: How an innovative cup can save lives

Breast milk is the perfect first food for newborns; it provides nutrients and energy that infants need and contains substances that strengthen their immune systems.

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Research Roundup: a Chagas vaccine, new pediatric clinical trial resources, the “Nursery of the Future,” and more

Sabin Vaccine Institute—a member of GHTC—and Texas Children’s Hospital Center for Vaccine Development received a US$1.8 million grant to expedite the research and development of the first therapeutic vaccine for Chagas disease, which is currently undergoing preclinical research by the same team.

GHTC
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New legislation aims to #SaveMomsandKids everywhere

In this guest post, Heather Ignatius—senior policy and advocacy officer at PATH—writes about a new bipartisan piece of legislation to accelerate progress towards ending preventable child and maternal deaths.

PATH
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New report on investment in R&D for HIV prevention highlights 2014 global funding trends

In this guest post, the HIV Vaccines & Microbicides Resource Tracking Working Group—comprised of AVAC as secretariat, the International AIDS Vaccine Initiative, and UNAIDS—discusses its new report examining investment in research and development (R&D) for HIV prevention options.

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Entering the Shark Tank for maternal and newborn health innovation

Last Wednesday 53 teams of innovators gathered at the International Trade Center in Washington, DC, for the Saving Lives at Birth DevelopmentXChange—an event resembling a cross between a science fair and an episode of Shark Tank.

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Research Roundup: a dengue vaccine, a breakthrough HIV treatment, antimicrobial R&D, and more

Later this year, French pharmaceutical company Sanofi plans to launch a vaccine for dengue fever, the first on the market for an infection for which nearly half of the world’s population is at risk.

GHTC
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