Breakthroughs Blog: Zika

In recognition of World Mosquito Day on August 20, 2021, GHTC is testing our readers’ knowledge of mosquito-borne diseases and ongoing efforts to develop treatments, vaccines, vector-control innovations, and other tools to outsmart the world’s deadliest animal. Find out if you have achieved mozzie mastery by taking our quiz below. Loading...(function(i,s,o,g,r,a,m){var ql=document.querySelectorAll('A[quiz],DIV[quiz],A[data-quiz],DIV[data-quiz]'); if(ql){if(ql.length){for(var k=0;k

In recognition of World Mosquito Day 2020, GHTC is testing our readers’ knowledge of mosquito-borne diseases and ongoing efforts to develop treatments, vaccines, vector-control innovations, and other tools to outsmart the world’s deadliest animal.Find out if you have achieved mozzie mastery by taking our quiz below.Loading...(function(i,s,o,g,r,a,m){var ql=document.querySelectorAll('A[quiz],DIV[quiz],A[data-quiz],DIV[data-quiz]'); if(ql){if(ql.length){for(var k=0;k

Interested in more global health innovation news? Every week GHTC scours media reports worldwide to deliver essential global health R&D news and content to your inbox. Sign-up now to receive our weekly R&D News Roundup email.  A vaccine candidate for gestational malaria, known as PRIMVAC, has yielded promising results in a small clinical trial evaluating its safety and effectiveness. PRIMVAC was shown to be well-tolerated and to elicit an immune response in 100 percent of the 68 non-pregnant women vaccinated after only two injections and for up to 15 months after the initial vaccination. Malaria is particularly dangerous to pregnant women because the red blood cells infected with the Plasmodium falciparum parasite that causes malaria accumulate in the placenta, promoting anemia and gestational hypertension. Gestational malaria is also linked to a higher risk of spontaneous abortion, premature birth, and intrauterine growth delays leading to low birth weight and a high rate of neonatal mortality. Future clinical trials will focus on studying the immune response elicited by PRIMVAC longer term. Last Tuesday, the US Food and Drug Administration (FDA) issued an emergency use authorization of a diagnostic test for the novel coronavirus (2019-nCoV) that has emerged in China, sickening more than 20,000 people and killing 427 globally. This exemption will make the test—developed by the Centers for Disease Control and Prevention (CDC)—available to public health labs across the United States and around the world in an effort to contain the disease’s spread. CDC has already shipped the test to a repository where states and international partners can order it. The nonprofit Foundation for Innovative New Diagnostics (FIND)—which works to expand diagnostic capacity in low-resource countries—is now using viral isolates of 2019-nCoV to evaluate the CDC’s diagnostic test and others like it. Scientists at the Walter Reed Army Institute of Research (WRAIR) have shown for the first time that a single dose of an experimental Zika vaccine, ZPIV, in individuals previously infected by dengue can boost pre-existing immunity and elicit antibody responses against both Zika and dengue. This result was compared to trial volunteers with no prior exposure to dengue who required two vaccinations of ZPIV to reach a similar magnitude of Zika antibody responses. These findings indicate that an effective Zika vaccine could boost dengue virus immunity and generate Zika antibodies that have the potential to be a prevention tool in regions where both diseases are endemic. In three phase 1 human clinical trials the ZPIV vaccine, developed by WRAIR, has shown to be safe and well-tolerated in healthy adults and to induce a robust immune response.

Faces of Innovation—a new GHTC project that features scientists on the front lines of research and development on new global health tools and technologies—profiles Dr. James Mutunga, who we met at the American Society of Tropical Medicine and Hygiene (ASTMH) Annual Conference, who does research on developing and testing new methods of controlling vector-borne diseases as well as pathogen surveillance in arthropod disease vectors at the US Army Medical Research Directorate-Africa in Kisumu, Kenya. My Name: James Mutunga, PhDWhere I work: US Army Medical Research Directorate-Africa in Kisumu, KenyaI’m funded by: US DoDThe views I express here are my own and do not and are not to be construed as official, or as reflecting true views of the Department of the Army or the Department of Defense. My research: I work on surveillance for vectors—that is, arthropod disease vectors. I work in the Entomology lab in Kisumu. Under the surveillance program, we do collection of field samples of mosquitoes, ticks, mites, fleas, any arthropod that we can imagine, sandflies included—we bring them to the lab and we do pathogen testing to detect diseases that they may carry. We also do morphological and molecular identification of these vectors. Eventually, what we create is a heat map of potential pathogens in circulation and the areas they are circulating so we can advise on the areas that are high-risk and therefore give this information to the US Army for deployment purposes, and protection. The vectors we currently mostly target are mosquito vectors. These transmit malaria, dengue, Zika, chikungunya, and many other different diseases. Motivation: A couple of years ago, I worked for a research institution that primarily researches on arthropod vectors called the International Center for Insect Physiology and Ecology, based in Nairobi, Kenya. And from there, my passion for mosquito research transitioned to what I undertook for my masters and my PhD. I undertook my PhD at Virginia Tech here in the US, and I worked on developing new carbamate molecules and testing them for malaria control. So that kind of invoked my passion, given that it is a disease [with] a broad burden [in] the world. That still is the focus of the work that I do, and I enjoy it.Why federal support is critical: The work we do, and the many years that the US government has invested in vector-borne disease research and control, is commendable. We still do not want to relent. We are facing challenges in vector control. We are having problems [with] insecticide resistance, we are having problems of changing vector behavior, and therefore, the investment in terms of financial support for researchers in the US—and all over the world—is more than needed. We are having challenges with the issues of climate change and habitat change—places that never used to have disease transmission are actually now having active indigenous transmission and therefore there is a need to continue investing and ensuring that policies that are being made to support this research.When I’m not in the lab: I spend time with family, friends. I like traveling, doing road trips. I also like charity work.