Formally shapes the global agenda for R&D through joint policy mechanisms endorsed by member states.
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A complex network of multilateral organizations contributes to the research and development (R&D) and delivery of vaccines, treatments, diagnostics, and other technologies to advance global health.
This resource provides an overview of each organization and how it contributes across six R&D areas, as well as denotes participation in three key umbrella partnerships below.
Formally shapes the global agenda for R&D through joint policy mechanisms endorsed by member states.
Research & Product Development
Directly engages in or finances research and clinical development of new vaccines, treatments, diagnostics, and other biomedical health products.
Provides substantial financing for product development and/or R&D capacity-building programs.
Conducts or facilitates the regulatory approval of health technologies.
Directly contributes to strengthening the capacity of low- and middle-income countries (LMICs) to conduct R&D.
Introduction & Access
Supports LMICs in introducing and scaling up access to health technologies through procurement, implementation research, technical assistance, etc.
Access to Covid-19 Tools Accelerator (ACT-A)
Denotes partners in ACT-A, a global collaboration to accelerate development and equitable access to COVID-19 technologies.
Global Action Plan for Healthy Lives and Well-Being for All (GAP)
Denotes implementing partners on GAP, a global framework to align efforts to accelerate progress toward the United Nations (UN) Sustainable Development Goals (SDGs).
Tech Access Partnership
Denotes partners in this UN initiative to increase access to COVID-19 technologies by providing a partnership platform and technical guidance to help LMICs strengthen manufacturing and production capabilities.
Click to expand. Hover over icons and symbols for category names.
Partnership that brings together public, private, and philanthropic organizations to finance and coordinate the development and manufacturing of vaccines and platform technologies against emerging infectious diseases. CEPI operates as both a funder and a facilitator, pooling contributions from governmental and nongovernmental donors to finance R&D conducted by grantee partners as part of a coordinated global approach. CEPI’s target diseases are informed by WHO’s list of priority pathogens with epidemic potential and the R&D Blueprint.
Global nonprofit partnership dedicated to accelerating antibacterial innovation by investing in early-stage development of new antibiotics, vaccines, rapid diagnostics, and other tools. CARB-X operates as a pooled financing mechanism and facilitator, leveraging resources from its funding governments and philanthropic partners, to finance a portfolio of R&D projects conducted by industry, academic, and nonprofit partners.
Forum that brings together the world’s seven leading economies to discuss and establish shared priorities for economic development and health. Outcomes and commitments, established through the Health Ministerial Meeting, Finance Ministerial Meeting, and Leaders’ Summit, can influence each nation’s individual investments in health R&D. Members include Canada, France, Germany, Italy, Japan, the United Kingdom, and the United States.
Forum that brings together the world’s twenty leading economies to discuss and establish shared priorities for economic development and health. Outcomes and commitments, established through the Health Ministerial Meetings, Joint Health and Finance Ministers Meeting, and Leaders’ Summit, can influence each nation’s individual investments in health R&D. Members include Argentina, Australia, Brazil, Canada, China, the European Union, France, Germany, India, Indonesia, Italy, Japan, Mexico, Russia, Saudi Arabia, South Africa, South Korea, Turkey, the United Kingdom, and the United States.
Public-private partnership that brings together donor and developing country governments and other development entities to expand access to vaccines in low-income countries. With donor funding, it provides financial support to eligible countries to procure vaccines and equipment for their immunization programs. By creating a high-volume, predictable demand for vaccines, it is able to work with manufacturers to negotiate lower prices for these vaccines and ensure a sustainable market.
Additionally, for select diseases like pneumonia, Ebola, and COVID-19, it has also initiated advance market commitments to incentivize vaccine R&D. While Gavi does not directly fund product development, its efforts help shape the vaccine market to incentivize R&D.
UNICEF, WHO, and the World Bank hold permanent seats on the Gavi governance board. Gavi also co-leads, alongside WHO and CEPI, the vaccines pillar of ACT-A, which is focused on developing and ensuring equitable global access to COVID-19 vaccines.
Nonprofit partnership that brings together governments, industry, academia, and civil society to finance and support the development of new and improved treatments for drug-resistant infections and promote best practices and policy solutions to facilitate their regulatory approval, procurement, affordability, and appropriate use.
GARDP was created by WHO and the Drugs for Neglected Diseases initiative, following a proposal endorsed by WHO member states, to help deliver on the WHO Global Action Plan on Antimicrobial Resistance.
Innovative financing mechanism that pools together funding from governments and philanthropic donors to provide catalytic capital and technical assistance to low- and lower-income country governments to help them develop, finance, and implement health programming to improve care for women, children, and adolescents. This support can be used by countries to introduce and scale up access to essential health technologies for these populations.
Partnership and innovative financing mechanism that raises funding from government, private, and philanthropic donors to finance programs, implemented by in-country partners and driven by country-defined needs, that reduce the impact of HIV/AIDS, tuberculosis (TB), and malaria in LMICs. With investments of more than US$4 billion a year, it is the world’s largest financier of AIDS, TB, and malaria prevention and treatment programs. Funding supports the distribution and scale-up of treatments and preventative therapies and tools, as well as technology pilot programs and service delivery innovations.
The Global Fund’s board features nonvoting representatives from WHO, the World Bank, UNAIDS, and the STOP TB Partnership to facilitate cross-coordination. The Global Fund also co-leads, alongside FIND, the diagnostics pillar of ACT-A, which is focused on development and scale-up of COVID-19 diagnostics, as well as the health systems pillar, alongside the World Bank, which is focused on crosscutting work to promote product access.
Partnership of more than 60 countries, as well as international organizations, nongovernmental organizations, and private-sector companies, to strengthen the capacity of countries to detect, prevent, and respond to infectious disease threats and drive progress toward full compliance with WHO’s International Health Regulations and other relevant global health security frameworks. Members jointly establish Action Packages, to facilitate collaboration toward agreed-upon objectives and targets, which then inform national strategies and activities to strengthen health preparedness. GHSA primarily serves as a body to set agendas, drive collaboration, and ensure accountability; it is not a substantial direct funder of health system strengthening activities.
International financial institution, financed by its member countries, that provides direct investment and advisory services to private-sector, for-profit projects that promote development and poverty reduction in LMICs. As part of its portfolio of investments, IFC has supported projects in LMICs to increase local manufacturing capacity for health technologies, strengthen supply chains for critical raw materials, and support health care service providers to expand delivery of and access to health products and services.
While IFC operates as a financially autonomous entity, it is part of the World Bank Group, which also includes the World Bank.
UN entity that works to catalyze and advocate for an accelerated, comprehensive, and coordinated global response to the HIV/AIDS pandemic. As part of its broader portolio of work, UNAIDS provides data, strategic guidance, and technical assistance to help LMICs implement and expand access to antiretroviral therapies, pre-exposure prophylaxis, and other HIV treatment and prevention technologies.
UN-backed international organization that works to lower the price of and expand access to essential medicines in LMICs through voluntary licensing and patent pooling. MPP negotiates with patent holders for licenses to allow generic manufacturers to produce generic versions of patented medicines for use in LMICs or to produce new derivative treatments, such as pediatric forumulations and fixed-dose combinations. By facilitating generic manufacturing and increased competition, MPP drives down the price of treatments to make them more affordable and accessible in LMICs. Its mandate covers medicines for HIV/AIDS, malaria, tuberculosis, hepatitis C, COVID-19, and other treatments on WHO’s list of essential medicines. MPP was founded and is funded by Unitaid.
Mechanism that supports LMICs in introducing and expanding access to affordable, quality-assured tuberculosis (TB) treatments and diagnostics via a bundle of packaged services tailored to country need. These services include access to a pooled procurement system for ordering products, technical assistance to facilitate introduction and uptake, and programmatic grants tied to performance. GDF also works with suppliers and stakeholders to monitor the adequate supply and sustainable pricing of products and standardizes packaging to simplify drug management for health programs. GDF is housed and administered by the Stop TB Partnership Secretariat, which sits within the UN Office for Special Projects.
International organization that advances innovations for HIV/AIDS, tuberculosis, malaria, and HIV coinfections. Unitaid invests in late-stage R&D for new drugs, diagnostics, and prevention tools; helps produce data supporting guidance on product use; and supports projects to generate market demand and facilitate the introduction and scale-up of these interventions. Funded primarily through airline taxes and supplemented with additional donor government and philanthropic contributions, it serves primarily as a grant-making organization that funds implementing partner organizations.
Unitaid is a hosted partnership of WHO, which holds a seat on its Executive Board, and it founded and funds MPP. It also co-leads the therapeutics pillar of ACT-A, alongside Wellcome Trust, which is focused on developing and ensuring equitable global access to COVID-19 treatments.
UN agency responsible for providing humanitarian and development aid to children worldwide. Among its broader portfolio of activities, UNICEF supports health R&D by developing target product profiles to communicate product needs for maternal, newborn, and child health (MNCH) and directly finances projects to develop MNCH technologies, with a primary focus on devices and tools. UNICEF also funds efforts to scale up essential MNCH technologies in LMICs and strengthen cold chains, and it is the world’s largest single buyer of vaccines, procuring more than 2 billion doses annually for programs in more than 100 countries. UNICEF is funded by contributions from governments and private and philanthropic donors and carries out work through regional and country offices worldwide.
As part of the COVID-19 response, UNICEF will lead efforts to procure and supply vaccines and immunization and cold chain technologies for LMICs as part of ACT-A’s vaccines pillar, which is co-chaired by WHO, Gavi, and CEPI.
UN agency responsible for UN’s global development activities. It seeks to connect countries to knowledge, expertise, and technical and financial resources to address global development challenges and drive progress toward the SDGs. As part of its broader portfolio of health work, which is funded by voluntary contributions from UN member states, UNDP supports programming, including the Access and Delivery Partnership, to help LMICs strengthen policies, human resources, systems, and regulations to expand access to essential medicines, vaccines, diagnostics, and other tools.
UNDP is a founding partner, alongside WHO, the UN Technology Bank, and the UN Conference on Trade and Development, of the Tech Access Partnership, which works to increase access to COVID-19 technologies by providing a partnership platform and technical guidance to help LMICs strengthen manufacturing and production capabilities. The UNDP administrator is also the vice-chair of the UN Sustainable Development Group, which unites the work of UN agencies that play a role in development including UNAIDS, UNFPA, UNICEF, and WHO.
UN agency responsible for advancing sexual and reproductive health. Among its broader activities, UNFPA directly procures contraceptives and reproductive health supplies to provide quality assurance and volume pricing for governments and nonprofits, and it provides technical assistance and supports implementation research to help countries introduce and scale up sexual and reproductive health interventions. UNFPA is funded through contributions from governments and private donations and works through partnerships with governments, other UN agencies, nonprofits, and the private sector to support programming in more than 150 countries.
UN program to strengthen science, technology, and innovation capacity in the world’s least developed countries. It undertakes a number of activities that broadly support health R&D capacity-building and technology adoption in least developed countries, including strengthening National Academies of Science, providing free or low-cost access to published academic research and professional content, and assessing gaps to provide recommendations to countries to improve technological capacity. It is also working to expand its activities to provide training and technical assistance on intellectual property rights, support technology transfer, and create regional innovation hubs.
The UN Technology Bank also leads the Tech Access Partnership, launched with support from UNDP, WHO, and the UN Conference on Trade and Development, which works to increase access to COVID-19 technologies by providing a partnership platform and technical guidance to help LMICs strengthen manufacturing and production capabilities.
International financial institution, funded by its member countries, that provides loans and grants to the governments of LMICs to finance infrastructure and social service improvements. As part of its broader portfolio of disbursements, the World Bank has provided financing and technical assistance to help countries procure health technologies and supplies for immunization and other health delivery programs, as well as build and equip public health laboratories to improve diagnostic, surveillance, and research capacity.
As part of the COVID-19 response, the World Bank co-chairs, alongside the Global Fund, ACT-A’s health systems pillar, which conducts crosscutting work to facilitate access to COVID-19 technologies, and it is providing direct financing to help countries purchase and distribute COVID-19 tools to their citizens.
The World Bank comprises two institutions, the International Bank for Reconstruction and Development and the International Development Association, and houses GFF, and is part of the World Bank Group, which includes IFC. Furthermore, it participates in a number of global partnerships including Gavi and UNAIDS.
UN agency responsible for international public health. WHO’s work is governed by the World Health Assembly, a decision-making body comprised of its member states, and is financed by assessed and voluntary contributions from member states, as well as contributions from philanthropic donors.
WHO contributes to the research, development, and delivery of health technologies in numerous ways:
Beyond the multilateral institutions listed above, there are several key regional and internationally focused entities supporting the global health R&D ecosystem.
For example, regional regulatory bodies like the European Medicines Agency and the nascent African Medicines Agency play a critical role in regulating health products and advancing regulatory harmonization. Regional developments banks—including the African Development Bank, Asian Development Bank, European Bank for Reconstruction and Development, and Inter-American Development Bank—provide financing to support different R&D activities, depending on the institution, including R&D capacity-building, procurement, and product development. The European and Developing Countries Clinical Trials Partnership brings together European and sub-Saharan African governments to finance clinical development of health technologies for neglected diseases and strengthen African research capacity.
Philanthropic donors, most notably the Bill & Melinda Gates Foundation and Wellcome Trust, play a significant role in directly financing global health research and product development, through academic institutions, product development partnerships, and private companies, as well as supporting R&D capacity-building in LMICs and the activities of several of the multilateral institutions listed above.
In response to COVID-19, several new global partnerships have also been stood up to specifically support COVID-19 R&D. The most notable is ACT-A, which was launched to accelerate development, production, and equitable access to COVID-19 tests, treatments, and vaccines. Its partners include the Gates Foundation, CEPI, FIND, Gavi, the Global Fund, Unitaid, Wellcome Trust, WHO, and the World Bank. Researchers and advocates have also launched new structures to advance scientific collaboration and capacity-building for COVID-19, such as the COVID-19 Clinical Research Coalition and the COVID Advocates Advisory Board.