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Interested in more global health innovation news? Every week GHTC scours media reports worldwide to deliver essential global health R&D news and content to your inbox. Sign up now to receive our weekly R&D News Roundup email.A study published last week found that an experimental influenza vaccine that uses messenger RNA (mRNA) technology protected against all known flu subtypes in animals. If found to be successful in humans, the universal vaccine, which would serve as a supplement to annual flu shots, could prepare the immune system to better respond to new flu viruses, reducing the likelihood of severe disease and death. These promising results come after years of efforts to develop a universal flu vaccine. While human trials are expected to begin soon, challenges including potential low tolerability of the mRNA vaccine will need to be addressed before the candidate can progress.A recently published study estimated that approximately 7.7 million people were killed by bacterial pathogens in 2019—the second leading cause of death globally that year. More than half of these deaths resulted from five pathogens: Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae, Klebsiella pneumoniae, and Pseudomonas aeruginosa. While the highest mortality rates occurred in sub-Saharan Africa, disproportionately high burdens are present throughout low- and middle-income countries, which could be linked to inadequate access to effective antimicrobials (which exist for all the bacteria investigated in the study), among other structural challenges. Despite the high burden of deaths associated with bacterial pathogens, they receive much less funding and attention compared to other diseases. These data underline the need for greater investment into a variety of interventions and innovations, including vaccine candidates, that can address drug-resistant bacterial pathogens.A recent study determined that an antibody (DH1017.IgM) found in pregnant women who were infected with Zika but did not pass the virus to their fetuses can protect mice from the virus and suppress it to an undetectable state in their blood. The study, which began during the 2015 Brazilian Zika outbreak, could lead to the use of the antibody as a therapeutic agent and prophylactic to protect at-risk patients during an outbreak. The research team is working next to discover whether the antibody can prevent transmission from pregnant mice to their offspring and hoping to progress to human trials that include pregnant individuals who are often excluded from drug trials. Preclinical research into other vaccine candidates for Zika are also underway.

Interested in more global health innovation news? Every week GHTC scours media reports worldwide to deliver essential global health R&D news and content to your inbox. Sign up now to receive our weekly R&D News Roundup email.Last week, Moderna announced that its new booster shot targeted at the omicron subvariant of COVID-19 raises immune protection against subvariants by increasing levels of omicron-blocking antibodies up to 15 times pre-booster levels. Moderna also said that an early analysis showed that while the antibodies generated by the booster were less effective against the rapidly growing BQ.1.1 subvariant, they could still block it. This announcement follows similar positive findings that were released by Pfizer and BioNTech earlier this month about their own bivalent coronavirus vaccine booster. However, Novavax also recently released results showing that their bivalent booster did not show a stronger response than their original booster.Last week, an analysis done by researchers from TB Alliance, Stop TB Partnership, and the World Health Organization estimated that the BPaLM/BPaL treatment regimen for drug-resistant tuberculosis (DR-TB) could save governments up to US$740 million a year. Implementation of the all-oral, shorter regimen is estimated to be 40 to 90 percent less expensive than current drug regimens for DR-TB, when accounting for drug costs, healthcare costs, and patient-incurred costs. The cost savings from the new regimen coupled with the shorter time period and the fewer drugs that are easier to tolerate, BPaLM/BPaL could contribute to more people with DR-TB having access to treatment and improved treatment experiences.Last week, the World Health Organization (WHO) announced that WHO and the Ugandan government are planning to test three candidate Ebola vaccines in a clinical trial with the intent to help address the ongoing outbreak in the country. The first doses are expected to arrive this week, although it is unclear when exactly the trial will start. The vaccines being used in the trial include one produced by IAVI, one developed by the Sabin Vaccine Institute, and a final developed by the Jenner institute at the University of Oxford. While there have been questions about the usefulness of the trial if it concludes after the outbreak ends, the results of the trials could provide essential information that will help prevent future Sudan Ebolavirus outbreaks even if it concludes after the current outbreak. Additionally, the trial design will enable all participants to receive a vaccine (though some will receive it after a delay) as opposed to a standard randomized controlled trial in which one group gets a placebo.