News

Interested in more global health innovation news? Every week GHTC scours media reports worldwide to deliver essential global health R&D news and content to your inbox. Sign up now to receive our weekly R&D News Roundup email.French researchers are investigating after 59 percent of individuals in a new mpox outbreak cluster claim to be vaccinated, raising fears that the virus has mutated. The investigation will look at various questions, including when the individuals were vaccinated and at what dose, as well as whether they share a common characteristic like having HIV that could impact the effectiveness of the vaccine. If other possibilities are ruled out, French health authorities will start looking at the possibility of a mutation in the virus. The vaccine, Imvanex or Jynneos, is a third-generation smallpox vaccine. There is no specific vaccine for mpox, and this investigation could yield important data about the real-life efficacy of this vaccine for the virus, which is expected to remain a public health issue.This week, German diagnostics startup Midge Medical announced a partnership with the Institut Pasteur de Dakar to offer a rapid molecular diagnostic test for Marburg virus for field testing on the African continent. The collaboration started with a request from the Institut to adapt the startup’s Minoo system, a portable, battery-operated, isothermal amplification instrument with smartphone connectivity enabling data analysis and readout of results, which was previously used for COVID-19 testing. Midge Medical said they integrated the Marburg virus test into the Minoo platform within a month and delivered a prototype assay and provided training to staff at the Institut for field testing, where it has been favorably received.German scientists have reported promising results for a nasal vaccine for COVID-19 tested in hamsters. While this vaccine is not yet close to rollout, other nasal vaccines have been in use in China and India since last fall (although studies about their effectiveness has not yet been published) and at least four other nasal vaccines for COVID-19 are in late-stage clinical trials. While strong data to back up these vaccines is still needed, the hope is that these next-generation vaccines could better prevent people from getting sick and spreading infection by blocking the virus at the point of entry in the nose and throat where it first gains a foothold.

As the G20 Health Working Group meets next week to consider political commitments to better prepare for future health threats and advance health equity, GHTC urges them to prioritize the following actions to bolster global research and development (R&D) capabilities:Support the creation of a new pandemic global medical countermeasures platform: The COVID-19 pandemic has made clear that the world needs a global, end-to-end coordination platform to facilitate the rapid development, manufacturing, and equitable delivery of medical countermeasures during health crises. G20 nations should commit to supporting and financing a new platform that builds on lessons learned from the Access to Tools Accelerator and prioritizes accountability, transparency, agility, and inclusivity in its approach.Fully fund the World Bank Pandemic Fund. To date, the fund has secured just US$1.6 billion in pledges against its $10.5 annual target. G20 leaders should also ensure the fund invests in projects to strengthen laboratory, clinical research, and regulatory capacity to advance the development of and access to health technologies, work that is complementary to that of other international health initiatives. Increase investment in R&D for poverty-related and neglected diseases (PRNDs). The pandemic has diverted critical resources and attention away from battles against longstanding global health challenges like HIV/AIDS, malaria, tuberculosis, and neglected tropical diseases. To reinvigorate these fights, G20 nations should boost funding and incentives for PRND R&D and support product development partnerships, which are uniquely equipped to advance technologies that are affordable, accessible, and adapted to the communities who need them. Center the needs of women, children, and other vulnerable populations in R&D. This includes enacting policies to improve collection and analysis of sex- and gender-disaggregated data and to ensure adequate representation of women, pregnant and lactating individuals, and other underrepresented populations in clinical trials. G20 nations should also work with the World Health Organization to develop target product profiles to advance therapeutic formulations for children, pregnant individuals, and other at-risk populations. Reprioritize R&D to combat antimicrobial resistance (AMR). The G20 has demonstrated past leadership on AMR research through its support of the Global AMR R&D Hub. G20 nations should build on this by continuing to support hub operations and increasing investments and incentives for R&D for new and improved antimicrobials, point-of-care diagnostic devices, vaccines, and other technologies required to stay ahead of this rising threat.Integrate R&D into pandemic prevention, preparedness, and response mechanisms. As negotiations continue on the pandemic accord and reforms to the International Health Regulations (IHR), G20 nations should push for the accord to embrace a holistic approach to supporting end-to-end product development and for the IHR to include new amendments to promote R&D coordination and genetic sequence sharing and new indicators to assess R&D capabilities at the country level.It is our hope that the commitments of this year’s G20 will chart a new path toward realizing a more resilient, fit-for-purpose, and equitable R&D ecosystem.

At next month’s G7 Health Ministers meeting, G7 leaders will be considering political commitments that could impact the health and well-being of millions of people around the world. As G7 nations consider reforms to realize a more fit-for-purpose global health architecture, GHTC urges them to prioritize the following actions to strengthen research and development (R&D):Advance the “100 Days Mission PLUS,” which aims to reduce the impact of future pandemics by developing and making medical countermeasures available within 100 days. To achieve this, G7 nations should strongly invest in the Coalition for Epidemic Preparedness Innovations, FIND, public health institutes, and regional manufacturing hubs, as well as scope and develop an international clinical trials network for coordinated testing and enhanced global regulatory collaboration.Fully fund the World Bank’s Pandemic Fund. To date, the fund has secured just US$1.6 billion in pledges against its $10.5 annual target. G7 leaders should also ensure the fund invests in projects to strengthen laboratory, clinical research, and regulatory capacity to advance the development of and access to health technologies, work that is complementary to that of other international health initiatives.Increase investment in R&D for poverty-related and neglected diseases (PRNDs). The pandemic has diverted critical resources and attention away from battles against long-standing global health challenges like HIV/AIDS, malaria, tuberculosis, and neglected tropical diseases. To reinvigorate these fights, G7 nations should boost funding and incentives for PRND R&D and support product development partnerships, which are uniquely equipped to advance technologies that are affordable, accessible, and adapted to the communities who need them. Center the needs of women, children, and other vulnerable populations in R&D. This includes expanding the activities of the G7 Gender Equality Advisory Council, as well as enacting policies to improve the collection and analysis of sex- and gender-disaggregated data and ensuring adequate representation of women, pregnant or lactating individuals, and other underrepresented populations in clinical trials. G7 nations should also work with the World Health Organization to develop target product profiles to advance therapeutic formulations for children, pregnant individuals, and other at-risk populations.Re-prioritize R&D to combat antimicrobial resistance (AMR). G7 countries have demonstrated past leadership on AMR research through support of the Global AMR R&D Hub. G7 nations should build on this by continuing to support hub operations and increasing investments and incentives for R&D for new and improved antimicrobials, point-of-care diagnostic devices, vaccines, and other technologies required to stay ahead of this rising threat. Integrate R&D into pandemic prevention, preparedness, and response mechanisms. As negotiations continue on the pandemic accord and reforms to the International Health Regulations, G7 nations should push for the accord to embrace a holistic approach to supporting end-to-end product development and for the International Health Regulations to include new amendments to promote R&D coordination and genetic sequence sharing and new indicators to assess R&D capabilities at the country level.GHTC hopes that commitments made at this year’s G7 will take us one step closer to realizing a more resilient and equitable R&D ecosystem capable of delivering the tools needed to confront long-standing and emerging health threats.

GHTC sent letters to House and Senate appropriations subcommittees: the Subcommittee on Labor, Health and Human Services, Education, and Related Agencies (LHHS); the Subcommittee on State, Foreign Operations, and Related Programs (SFOPS); and the Subcommittee on Defense, urging these subcommittees to sustain and protect global health research and development funding in the fiscal year 2024 (FY24) budget.Subcommittee on Labor, Health and Human