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In this regular feature on Breakthroughs, we highlight some of the most interesting reads in global health research from the past week. GAVI, the Vaccine Alliance has partnered with the wearable tech company Kushi Baby to bridge the immunization gap for infants in low-income communities. About 1.5 million children die every year from vaccine-preventable illnesses, and one in three do not receive the immunizations they need simply because health professionals "do not know they exist." This partnership will provide children with a wearable necklace technology that remotely tracks and updates their immunization history. The technology allows health professionals to more accurately provide the supplies needed when traveling to rural communities and reach children in need of immunization. This year 1,500 infants in Northern India received the necklaces. The partnership has a goal of increasing distribution to 5,000 necklaces by the end of the year. A new vaccine under development may lower pneumonia incidence and mortality rates by targeting additional strains of the bacteria, according to a new study published in Science Advances. Current pneumonia vaccines only target the most common strains of the illness, but this vaccine candidate targets dozens of additional strains. The candidate may also help maintain the body’s microbiome—a collection of healthy bacteria often killed during the immunization process—by “attack[ing] [bacteria] only if it breaks away from the colony to cause an illness.” The World Health Organization Strategic Advisory Group of Experts on Immunization (SAGE) has recommended a new typhoid fever vaccine that has demonstrated up to 87 percent effectiveness during a clinical study. This typhoid vaccine is the first of its kind licensed for use in children under two years of age. SAGE recommended the vaccine be given to children 6 months old and that catch-up campaigns be administered to immunize children between the ages of 6 months and 15 years of age. With drug-resistant typhoid growing in typhoid-endemic communities, the vaccine will also be a valuable tool in combatting antimicrobial resistance.  

In this regular feature on Breakthroughs, we highlight some of the most interesting reads in global health research from the past week. Researchers at the 48th Union World Conference on Lung Health highlighted three promising innovations that have the potential to modernize the tuberculosis (TB) diagnostic and treatment landscape. The first innovation builds upon the current therapy monitoring protocol, which involves directly observing patients to ensure they take their medicines, in a novel and contemporary way. The new system, Remote Observation Therapy (ROT), uses an edible sensor and a wearable patch to remotely track whether patients are taking their TB medicine and assist public health professionals with treatment monitoring to ensure that patients continue and complete TB therapies. The second is an oral swab alternative to sputum tests. Current sputum tests are difficult to collect and pose various problems for patients who need to produce the sample. Instead, a simple cheek swab has delivered promising results, though the swab will still require analysis from a GeneXpert or a similar machine. Lastly, a new, rapid prototype blood test, which can detect TB in as few as 15 minutes and requires no electricity and limited medical training, is showing promise. This diagnostic tool would address a major gap in blood-based TB diagnostics. A new, oral therapy has shown promising results in clinical trials for curing sleeping sickness, a debilitating disease that affects the neurological system.. The oral drug—fexindazole—cured 91 percent of patients with severe sleeping sickness and 99 percent of patients in the early stages of the disease. Fexindazole is a much-needed alternative to current combination therapies that involve a mix of pills and intravenous infusions, which can be challenging to administer in low-resource settings where infrastructure and highly trained health workers may be limited. Wellcome Trust, with assistance from the UK government and the Bill and Melinda Gates Foundation, has announced the Global Burden of Disease Antimicrobial Resistance (AMR) project , a new research initiative to track global data on drug-resistant infections and deaths. Over four years, the project will compile relevant data, produce detailed maps for intervention and clinical purposes, and provide publicly available visual representations on AMR’s global burden. This project will allow governments and researchers to strategically target global efforts to combat AMR.