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For the third consecutive year, the Trump administration has proposed significant cuts to critical government programs that advance innovation to improve the health of millions of people in need around the world, including Americans. The Global Health Technologies Coalition (GHTC) is deeply concerned by President Trump’s fiscal year (FY) 2020 budget proposal. If enacted, the funding reductions proposed would undermine the United States’ legacy of global leadership in the development of vaccines, drugs, diagnostics, and other technologies for neglected diseases and conditions that affect the world’s most vulnerable people.The proposal cuts funding to global health research and development (R&D) at the US Agency for International Development (USAID), Centers for Disease Control and Prevention (CDC), and National Institutes of Health (NIH). If enacted, groundbreaking research and the creation of new tools to address the world’s greatest global health challenges would slow or stop. These cuts would also weaken global health security, undermining our ability to prevent and contain disease outbreaks. For example:The elimination of HIV/AIDS research funding at USAID in the proposal would threaten progress towards game-changing innovations to prevent HIV/AIDS. As the administration proposes bold goals to counter the HIV/AIDS epidemic in the United States, it is critical to continue supporting R&D for new approaches to defeat AIDS in America and beyond. This is just one example of this proposal’s potential impact on global health R&D in the International Affairs account—overall, the proposed 28 percent cut to global health programs at USAID and the State Department threatens decades of lifesaving progress and runs counter to our international interests.Reduced funding for CDC’s global health activities at the Center for Global Health (CGH) and the National Center for Emerging and Zoonotic Infectious Diseases (NCEZID) would further constrain an agency already under-resourced to address the magnitude and range of health challenges we face. While GHTC welcomes the administration’s continued commitment to and investment in global health security efforts, this increased funding should not come at the expense of other vital CGH programs that support R&D of technologies and other activities to detect, prevent, and respond to health threats. Likewise, proposed reductions to NCEZID programs that develop interventions to combat infectious diseases run counter to the administration’s global health security goals and will directly compromise domestic and international preparedness.The proposed cut of more than US$4.5 billion to NIH would erode America’s leadership in medical research—leadership Congress has bolstered by increasing funding for NIH by $5 billion over the past three years. Disproportionate cuts to the National Institute for Allergy and Infectious Diseases (NIAID) and the Fogarty International Center at NIH would jeopardize the development of new tools for global health threats like Ebola and undermine research collaborations with other countries who serve as key partners and allies in mitigating global disease threats.While the proposal’s cuts to global health programs at USAID, the State Department and essential research activities at CDC and NIH are worrisome, GHTC was pleased to see steady funding for the Biomedical Advanced Research and Development Authority and a funding boost for the Food and Drug Administration included in the budget request. These entities play important roles in the global health R&D ecosystem, and GHTC appreciates the administration’s recognition of their contributions.“The United States is the global leader in research and development of new tools for the world’s most pressing health challenges—benefiting Americans at home and communities around the world,” said Jamie Bay Nishi, GHTC’s Director. “Cutting funding for global health R&D programs at USAID, CDC, and NIH would undermine decades of patient investment in R&D which is on the cusp of delivering ground-breaking new tools to prevent, treat, and respond to the most pressing global health challenges and health emergencies. We have seen past budget cuts shelve promising research on tools for threats like Ebola and cannot afford to be caught empty-handed for the next health crisis.”Strong congressional support for global health R&D has maintained and increased funding for this lifesaving work despite past proposals for cuts by the Trump administration, and we urge Congress to continue its history of bipartisan support for global health and medical research and for a third year in a row reject this short-sighted budget proposal.

Interested in more global health innovation news? Every week GHTC scours media reports worldwide to deliver essential global health R&D news and content to your inbox. Sign-up now to receive our weekly R&D News Roundup email.On March 6, the World Health Organization (WHO) announced wide-ranging reforms in the organization’s structure intended to help it achieve its “triple billion” targets as part of its new five-year strategic plan—including one billion more people benefiting from universal health coverage, one billion more people better protected from health emergencies, and one billion more people enjoying better health and well-being. Among the reforms is the creation of a new chief scientist division formed “to strengthen WHO’s core scientific work and ensure the quality and consistency of WHO’s norms and standards.” Headed by Soumya Swaminathan who will serve as chief scientist, this division is also expected to offer and improve career opportunities for scientists at WHO. Other reforms include the creation of a new department of digital health, a division of emergency preparedness to complement WHO’s existing emergency response work, and a “WHO Academy” to train public health professionals. WHO officials have summed up the organizational transformation initiative as an effort to break down silos across WHO programs and ensure alignment among its offices worldwide. A new report released by the G20 Health & Development Partnership on March 5 urges finance ministers to help tackle some of the world’s most pressing global health challenges by developing new financing models and increasing concerted activity for research and development. The report calls for innovative solutions to funding health, citing that ill health could cost the world billions in treatment and lost economic productivity. Alan Donnelly, convener of the G20 Health & Development Partnership, stated that tackling these health challenges are “no longer just an issue for health ministers, it is now an issue for heads of government and for finance ministers because of the threat to the global economy as well as to humanity.” The partnership released the report in advance of the joint G20 health and finance ministers meeting in Japan in June as an appeal to the finance ministers to “remove the silo walls around health care.”For only the second time in history, a patient appears to have been cured of HIV. Like the first recorded case nearly 12 years ago, this outcome resulted from a bone marrow transplant initially intended to treat cancer. In both cases, transplants were from a donor with a mutation in a protein called CCR5, which rests on the surface of certain immune cells. The HIV virus uses this protein to enter those cells but cannot latch onto the mutated version. Although these transplants confirm for researchers that a cure for HIV is possible, bone marrow transplantation is unlikely to be a realistic treatment option in the near future due to the risk and harsh side effects involved—though rearming the body with immune cells modified to resist HIV may succeed as a practical treatment.

G20 health and finance ministers urged to bring about the necessary marriage between the wealth and the health of nations A global coalition of charities, businesses, product development partnerships and academics have come together to say the G20 is failing to meet today’s urgent health challenges and this will only be solved if heads of government and finance ministers take charge to stop this severe threat to the global economy as well as to humanity. The G20 Health and Development Partnership – representing 21 leading global organisations and more than 1000 collaborators – will today urge G20 heads of government and finance ministers to join health ministers in addressing the growing disease burden before it is too late. It is predicted that the number of deaths in the G20 countries from non-communicable diseases, such as cancer, heart diseases and diabetes will double by 2030 if urgent steps are not taken now. Together with the fact that tuberculosis still remains the number one killer globally, the rise of drug resistance amongst infectious diseases pose an existential threat to society. The report, which is being launched in the UK parliament today (Tuesday 5th March) calls on G20 heads of government and finance ministers to ‘take ownership’ of this issue similar to their efforts combatting climate change - rather than just leave it to health ministers. The economic consequences in low- and middle income countries of the increasing disease burden is unsustainable if not addressed. The partnership is presenting the report to the heads of government finance and health ministers in advance of the joint G20 health and finance ministers meeting in Japan this June. Lord Jim O’Neill, chair of the Royal Institute of International Affairs Chatham House London, said: “This report by the G20 Health and Development Partnership is an appeal to G20 finance ministers to remove the silo walls around health care to see what can be done to make a link between the health and the wealth of our nations. “It sets out to support the need to invest in human capital in terms of global health. It is a holistic approach that blends economics and health so that the wealth and the health of nations are united in a new priority for government, society and the economic actors in the rest of the century. “I would like the G20 health and finance ministers to bring about the necessary marriage between the wealth and the health of nations.” Alan Donnelly, Convener of the G20 Health and Development Partnership and Executive Chairman of Sovereign Sustainability and Development, said: “The richest nations of the world will miss their own health global goals unless governments recognise the existential nature of the threat, make it a priority for leaders, and develop new partnerships because government funding isn’t going to fix this alone. “This is no longer just an issue for health ministers, it is now an issue for heads of government and for finance ministers because of the threat to the global economy as well as to humanity. “The G20 Health and Development Partnership, which emerged during the course of the German presidency in 2017, works to ensure that G20 countries are coordinating their health innovation strategy to tackle the growing burden of communicable and non-communicable diseases globally. “This year the G20 can set in motion steps to examine new ways of funding innovation in health and encourage the establishment of mechanisms that will help to fund the diagnostics, vaccines and medicines that are so urgently required globally.”