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Interested in more global health innovation news? Every week GHTC scours media reports worldwide to deliver essential global health R&D news and content to your inbox. Sign up now to receive our weekly R&D News Roundup email. Last week, Detect Diagnostics announced that it received approximately $5.9 million in grants from the Bill & Melinda Gates Foundation to support further development of the company’s infrared light-based point-of-care system and assays to detect protein biomarkers of infectious disease. The Visualization by Infrared PEptide Reaction (or VIPER) diagnostic technology can detect bacteria, viruses, and fungi directly from samples and is simple to use, fast, low-cost, sensitive, and portable, making it suitable for low- and middle-income countries, which face a high burden of infectious disease. The grants include specific funding to advance the development of a test to detect tuberculosis.Last week, the National Institute of Allergy and Infectious Diseases and Siga Technologies announced that patients are no longer being enrolled in a clinical trial testing the antiviral drug tecovirimat (or Tpoxx) as a treatment for mpox. The study’s Data Safety and Monitoring Board recommended cessation after the drug did not hasten lesion healing or pain relief in adults with mild to moderate clade 2 mpox at low risk for severe illness, and an additional assessment showed a less than 1 percent chance that the study would demonstrate efficacy if enrollment and follow-up were completed. This news comes amid the ongoing global outbreak of clade 1 mpox and following the 2022 global outbreak of clade 2 mpox. While this trial and another testing Tpoxx for mpox did not show that the drug helped to accelerate lesion healing, before 2022, no treatment candidate had been studied in people with mpox, and this research represents an important step in the ongoing work of finding tools to address mpox.A recently published study introduces a proof-of-concept for a novel class of antivirals targeting a type of enzyme essential to several families of viruses—which include several pathogens that scientists believe are most likely to cause the next pandemic—, potentially paving the way for a faster and more robust response to future outbreaks. The research team screened hundreds of thousands of compounds, using the ones they discovered to create an optimized drug candidate that was then tested in mice, finding that the candidate could treat COVID-19 on par with Paxlovid, remain effective even if the virus mutated, and cause minimal side effects. The researchers say they need an industry partner before they can test the compound in humans, but they are working on developing compounds that could target other priority viruses that share the targeted enzyme, including RNA viruses like Ebola and dengue, as well as cytosolic-replicating DNA viruses like mpox.

Interested in more global health innovation news? Every week GHTC scours media reports worldwide to deliver essential global health R&D news and content to your inbox. Sign up now to receive our weekly R&D News Roundup email. A research team was able to induce broadly neutralizing antibodies targeting hepatitis C virus (HCV) in laboratory models for the first time, providing a promising approach for a vaccine targeting the virus, which an estimated 58 million people globally are chronically infected with and which causes 290,000 deaths annually. HCV is identified as a globally prioritized pathogen for vaccine research and development by the World Health Organization, but developing a vaccine has been a challenge due to the high genetic diversity of the virus. This new approach, if proven successful in further studies, could not only bring us closer to an effective HCV vaccine that could help limit the spread of the virus but could also lay the foundation for a new generation of vaccines against other priority viruses.Last week, the World Health Organization (WHO) announced that it had granted prequalification to Cepheid’s Xpert MTB/RIF Ultra rapid diagnostic test for tuberculosis (TB), the first TB diagnostic test to be prequalified by WHO. The designation will hopefully help ensure broader access to the product, allowing for accurate and early detection of TB, especially drug-resistant TB. Within hours, the test detects the genetic material of Mycobacterium tuberculosis in sputum samples and identifies mutations associated with rifampicin resistance, a key indicator of multidrug-resistant TB. A recent report found that 8.2 million people—the highest number of cases recorded by WHO since it began global TB monitoring—were diagnosed with TB in 2023, underscoring the need for greater access to new and improved tools.Last week, the World Health Organization (WHO) announced that it had granted prequalification to tafenoquine, the first single-dose medicine for the prevention of Plasmodium vivax malaria, and also included tafenoquine, co-administered with chloroquine, in the new WHO malaria guidelines for South America. P. vivax is the dominant malaria parasite in most countries outside of sub-Saharan Africa, with children under five and migrant populations at particular risk. The prequalification and inclusion of tafenoquine in the updated guidelines are aimed at improving access to the treatment, which is shorter and simpler than current treatment regimens.

The Global Health Technologies Coalition (GHTC) yesterday honored Senator Cory Booker (D-NJ), Senator Susan Collins (R-ME), and Congresswoman Chrissy Houlahan (D-PA) for their leadership in championing global health research and development (R&D) at its 2024 Innovating for Impact Awards, an annual initiative celebrating US policymakers and partnerships catalyzing global health innovation. GHTC also recognized the partners that developed and are accelerating global access to the novel oral polio vaccine type 2 (nOPV2)—a next-generation oral polio vaccine that is accelerating global polio eradication efforts—for their efforts to advance this groundbreaking new product.Senator Booker, who is chairman of the Foreign Relations Subcommittee on Africa and Global Health Policy, was honored with a Congressional Champion Award for his leadership in introducing the Supporting Innovative Global Health Technologies (SIGHT) Act to establish a new disease-agnostic R&D program at the US Agency for International Development (USAID), as well as his support of numerous other bills to bolster R&D for neglected diseases, antimicrobial resistance, and infectious disease monitoring. “Injustice anywhere is a threat to justice everywhere, in the same way that infectious disease anywhere is a threat to the justice, the safety, the peace, the health of all people everywhere,” Senator Booker said in accepting the award. GHTC also recognized Senator Collins, who is Vice Chair of the Senate Appropriations Subcommittee and a member of the Health, Education, Labor and Pensions Committee, with a Congressional Champion Award for the pivotal role she has played in protecting and expanding funding for global health research at the National Institutes of Health and other key US agencies, as well as her support of critical bills to advance global health research, including the Reach Every Mother and Child Act to advance innovative tools to end preventable child and maternal deaths. “As a leader of the Senate Appropriations Committee, I’ve long supported strong funding for global health programs…We have proven that compassionate, targeted foreign aid, in conjunction with private philanthropy, can save lives and improve health for millions of people all around the world,” Senator Collins stated in prerecorded acceptance remarks. Additionally, Congresswoman Chrissy Houlahan was celebrated with a Congressional Champion Award for her leadership in introducing the SIGHT Act to supercharge health innovation at USAID, as well as her co-sponsorship of other notable legislation to strengthen preparedness and response to health emergencies, including the Global Health Security and Global Pandemic Prevention and Biosecurity Acts. “Disease does not respect boundaries, and health emergencies are clearly continuing…so that’s the exact reason…that I’m supporting and introducing the Supporting Innovative Global Health Technologies Act,” Congresswoman Houlahan remarked in her acceptance speech. “It’s important that we work with our partners across government, across the nonprofit world, and of course, across the world of business…to make sure that we address issues such as disease,” she noted. Finally, GHTC presented the Partnership Award to Dr. John Konz, Global Head of Viral Diseases at PATH’s Center for Vaccine Innovation and Access,  who accepted the award on behalf of the many partners who contributed to the development and global rollout of nOPV2. This innovative vaccine has been engineered to be less likely than the original oral polio vaccine to cause vaccine-derived polio cases, and it protects against the type 2 strain of polio virus, which causes the majority of these cases. Though these cases are extremely rare, because the world has achieved such stunning success in reducing polio, these variant cases today outnumber wild polio cases, posing a significant barrier to eradication.nOPV2 was advanced from idea to impact thanks to a constellation of global partners. These include the Bill & Melinda Gates Foundation; Bio Farma; Cevaxin; the US Centers for Disease Control and Prevention; Fighting Infectious Diseases in Emerging Countries; the US Food and Drug Administration; icddr,b;   Intravacc; the London School of Hygiene & Tropical Medicine’s Medical Research Council Unit The Gambia; the United Kingdom’s Medicines and Healthcare products Regulatory Agency; UNICEF; the University of Antwerp; the University of California, San Francisco; the World Health Organization (WHO); and the Global Polio Eradication Initiative. In 2020, nOPV2 became the first-ever vaccine to be authorized for emergency use by WHO, and since then, more than a billion doses have been delivered to children in high-risk settings—bringing us closer to a polio-free world.“It’s been a privilege for PATH to lead and facilitate this project over the past nine years, and it’s an honor to accept this award on behalf of the people and the organizations that made this vaccine a reality,” said Dr. Konz. “It’s truly a story of 70 years of investments and innovation.”  “GHTC is thrilled to honor Senator Booker, Senator Collins, Congresswoman Houlahan, and the partners who advanced nOPV2 with our Innovating for Impact Awards,” said Dr. Kristie Mikus. “Strong political will and smart partnerships are key to delivering next-generation cures and vaccines to fight the world’s deadliest health threats. We’re delighted to recognize the outstanding work of our honorees who are making progress possible.”Now in its eighth year, the Innovating for Impact Awards celebrate US commitment to global health R&D and honor the multisector partnerships and policymakers helping to transform breakthrough scientific research into lifesaving technologies for unmet global health challenges. Learn more about the initiative and past honorees.View photos from the event on Flickr and Facebook.