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Interested in more global health innovation news? Every week GHTC scours media reports worldwide to deliver essential global health R&D news and content to your inbox. Sign up now to receive our weekly R&D News Roundup email. The Medicines Patent Pool (MPP) and ViiV Healthcare last week announced a new voluntary licensing agreement that would allow for generic manufacturing and distribution of long-acting cabotegravir in an effort to expand access to the HIV prevention drug. Long-acting cabotegravir—an injectable form of preexposure prophylaxis, or PrEP—can provide two months of protection against HIV infection with a single shot, while most other forms of PrEP require daily pills. The new licensing agreement between the United Nations-backed MPP and ViiV will let select generic manufacturers apply for sublicensing to develop, manufacture, and supply generic forms of the drug in 90 countries—pending regulatory approvals—where the HIV burden and potential use of cabotegravir is the highest.The Coalition for Epidemic Preparedness Innovations (CEPI) is supporting an initiative to develop a standardized approach to test the performance of vaccines being used or in development against monkeypox. The new funding, announced days after the World Health Organization declared monkeypox a public health emergency of international concern, will go to the UK Medicines and Healthcare products Regulatory Agency and the UK Health Security Agency to pursue tools able to assess the strength and duration of immune responses generated by current vaccines, as well as for tests used to detect monkeypox antibody levels. These tools will subsequently be made available to the global scientific community for free, apart from administration fees, enabling a standardized assessment between countries documenting vaccine performance against monkeypox, according to CEPI.Researchers have identified a specific area of the SARS-CoV-2 spike protein as a good target for pan-coronavirus vaccines, making a promising advance in the development of a shot to protect against COVID-19 variants and common colds. A universal coronavirus vaccine would need to induce antibodies that recognize and neutralize a wide range of viruses—a challenge, given the complexities of the coronavirus family, according to scientists. In the new study, scientists investigated whether antibodies targeting the S2 subunit of SARS-CoV-2’s spike protein could also neutralize other coronaviruses, including a strain of the common cold as well as several COVID-19 variants, and found promising results among mice. The researchers plan to continue to study the method as potential pan-coronavirus vaccine target and evaluate how it could be integrated with currently licensed vaccines.

The Global Health Technologies Coalition (GHTC) welcomes the decision this week by the Global Health Security Agenda (GHSA) Steering Committee to make permanent its pilot Research and Development (R&D) Task Force. This important decision gives the task force—which was launched in June 2021 as a one-year pilot effort focused on improving R&D readiness—a mandate to continue its work through the current GHSA strategic framework, which runs through 2024.In response to the decision, GHTC Executive Director Jamie Bay Nishi said, “GHTC and our members applaud the GHSA Steering Committee for making permanent the R&D Task Force—an action that not only enables it to continue its vital work, but also cements R&D capacity strengthening as a central part of GHSA’s broader mission to prevent, detect, and respond to health threats.”“The COVID-19 pandemic has made clear the importance of investing in R&D of medical countermeasures to combat health threats. But it has also exposed systemic gaps in the R&D capabilities of many nations—including limited surveillance, clinical research, manufacturing, and regulatory capacity—which have contributed to gross inequalities in access to health technologies between rich and poor nations. As a country-led collaborative effort, the GHSA R&D Task Force is uniquely positioned to play a leadership role in closing these gaps—and in just one year has already achieved important first steps toward that aim.”“Later this year, the task force will unveil a new tool designed to support countries in self-assessing their R&D capabilities, which aligns with and complements the International Health Regulations (IHR) and Joint External Evaluation (JEE) process. GHTC believes that at a local level, this tool can help GHSA nations identify country-specific R&D capacity gaps to address through their national preparedness plans, and at a global level, this evidence can inform the adoption of new indicators within the IHR or JEE to better address R&D readiness, as well as strategically guide the disbursement of funding from international mechanisms like the new World Bank prevention, preparedness, and response fund.”“Closing R&D capacity gaps is not a problem that will be solved overnight, but it is vital to bolstering the world’s pandemic defenses. We thank the GHSA Steering Committee for their vote of confidence to continue the task force’s work and their continued leadership and commitment to advancing a world better equipped with the R&D capabilities to prevent the next pandemic.”For more information on the GHSA R&D Task Force’s accomplishments and future vision, view its one-year progress report.