Breakthroughs Blog

Breakthroughs brings you stories of bright ideas and bold innovations in global health.

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Ansley Kahn
Research Roundup: Rotavirus vaccine may help protect against Type 1 diabetes, 1 million child-friendly TB courses ordered since 2016, and Trump orders agencies to trim advisory panels

In this regular feature on Breakthroughs, we highlight some of the most interesting reads in global health research from the past week.

Recent

New legislation would strengthen USAID’s role in global health R&D

Update: The Global Health Technologies Coalition is excited to announce that the Global Health Innovation Act (H.R. 2241) passed the House of Representatives on December 18.

GHTC
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Research Roundup: priority review voucher sells for record price, WHO action to address antimicrobial resistance, and more

The French pharmaceutical company Sanofi purchased a priority review voucher (PRV)—which entitles the owner to an expedited review of a future product by the US Food and Drug Administration (FDA)—for US$245 million last week.

GHTC
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21st Century Cures Act: What the global health community needs to know

Last week, the House Energy and Commerce Committee unanimously voted to approve the 21st Century Cures Act—a bill that aims to speed the development, approval, and introduction of new health technologies.

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CDC/Melissa Dankel
Research Roundup: US and European efforts to address growing antimicrobial resistance and legislation to advance medical breakthroughs

Members of the European Parliament are calling on the European Commission to adopt a resolution to combat the growing threat of antimicrobial resistance—which kills 25,000 Europeans annually.

GHTC
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PATH/Evelyn Hockstein
Four reasons now is the time to ramp up investment in HIV/AIDS vaccine R&D

This Monday, May 18 was HIV Vaccine Awareness Day (HVAD), and GHTC members AVAC, the International AIDS Vaccine Initiative (IAVI), and the Bill & Melinda Gates Foundation convened leaders in the field to discuss the state of HIV/AIDS vaccine research and development (R&D).

GHTC
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PATH/Christopher Nelson
Research Roundup: Big Pharma’s role in antibiotic R&D, clinical trials for Ebola vaccines and drug-resistant tuberculosis treatments, and more

How can we get Big Pharma to invest in low-cost antibiotic research and development (R&D)?

GHTC
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Will Boase
Research Roundup: inclusion of women in clinical trials, the future of vaccines, and diagnostics for counterfeit medicines and parasitic worms

United States Representatives Jim Cooper (D-TN) and Cynthia Loomis (R-WO) introduced the Research for All Act last week which calls for the inclusion of more women in clinical trials for products submitted for US Food and Drug Administration (FDA) approval.

GHTC
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Mothers of innovation: Five mothers who have transformed global health

Breakthrough ideas are like children—they start small, they need constant nurturing, they don’t always develop according to schedule, but they change lives forever.

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Seven takeaways on the post-2015 negotiations

Trying to navigate and understand the post-2015 negotiations can be a challenge, so to help add some clarity, last week the Global Health Technologies Coalition (GHTC) convened a panel of experts to help explain the ongoing debates and where the negotiations stand and how health innovation is reflected in the agenda.

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PATH/Lesley Reed
Research Roundup: leadership at USAID, investments in global health research at US universities, and measuring the impact of open innovation

United States President Barack Obama announced last week his intent to nominate Gayle Smith, senior director for Development and Democracy at the National Security Council, to lead the US Agency for International Development (USAID).

GHTC
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PATH/Evelyn Hockstein
Research Roundup: resistance to antimalarials in Africa, R&D for bioterrorist attacks, and more

Scientists at the London School of Hygiene and Tropical Medicine have identified a mutation in Plasmodium falciparum—the parasite responsible for the majority of fatal cases of malaria—that makes the parasite more resistant to quinine and artemisinin, the leading antimalarials worldwide.

GHTC
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Photo courtesy of the David and Lucile Packard Foundation.
Could climate change lead to chikungunya? Examining the link between climate change and health

Polar bears and penguins aren’t the only species threatened by climate change.

GHTC
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PATH/Patrick McKern
Research Roundup: publication of clinical trial results, the establishment of an African CDC, and more

The World Health Organization (WHO) released a statement last week calling for the publication of all data from clinical trials for drugs, vaccines, and medical devices.

GHTC
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PATH/Jennifer Fox
Research Roundup: research capacity building in Africa, lessons learned from the Ebola outbreak, and top health officials in the United States tell Congress to “think globally”

A new initiative seeks to develop research capacity within Africa and create a regional hub with the ability to determine research needs and award grants.

GHTC
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PATH/Gabe Bienczycki
Research Roundup: India to expand list of essential medicines, China’s emerging leadership in the pharmaceutical industry, WHO paves the way for hepatitis C generics, and more

India is expected to add all of the drugs currently used in the government’s HIV/AIDS and tuberculosis (TB) control programs to its list of essential medicines within the next six months.

GHTC
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PATH/Evelyn Hockstein
GHTC briefing highlights importance of global health innovation in protecting US and world from threats like Ebola

On Thursday, March 26, 2015, the Global Health Technologies Coalition (GHTC) launched its sixth annual policy report titled Meeting the challenge, seizing the opportunity: US leadership can advance global health R&D with a luncheon and panel discussion on Capitol Hill.

GHTC
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CDC
Research Roundup: clinical trials for experimental Ebola vaccines, genetic traits that affect malaria risk, and progress toward a hookworm vaccine

The National Institute of Allergy and Infectious Diseases (NIAID) announced last week that two experimental Ebola vaccines appear to be safe for widespread use, based on early results of clinical trials in Liberia.

GHTC
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PATH/Gabe Bienczycki
Research Roundup: new discoveries in the search for a malaria vaccine and tuberculosis treatment and lessons from the Ebola epidemic

A team of scientists at Heinrich-Heine Universität Düsseldorf have identified a potential new player in the fight against tuberculosis (TB).

GHTC
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US Centers for Disease Control and Prevention
Fighting for the future: Why we must come together to fight antibiotic resistance around the globe

I am pleased to have the opportunity to write about what is perhaps today’s most vexing public health challenge—the growing threat of antibiotic resistance.

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PATH/Gabe Bienczycki
Research Roundup: discoveries in malaria research, remaining barriers to the development of an Ebola vaccine, and a diagnostic for maternal survival

Scientists at Karolinska Institutet in Sweden have identified the protein that explains why people with blood type O are protected from coma and death resulting from severe cases of malaria.

GHTC
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