Breakthroughs Blog

Breakthroughs brings you stories of bright ideas and bold innovations in global health.

The Latest
Ansley Kahn
Research Roundup: 'Highly effective' way to kill malaria parasite, a mobile program to get TB patients to take their pills, and radiating mosquitoes to stop dengue fever outbreak

In this regular feature on Breakthroughs, we highlight some of the most interesting reads in global health research from the past week.

Recent

Transforming the lives of women and girls in sub-Saharan Africa and helping end AIDS through better HIV prevention research and development

In this guest post Tom Harmon, senior policy analyst at the International AIDS Vaccine Initiative (IAVI), and Anna Forbes, a globally recognized advocate for women’s HIV prevention needs, discuss a new piece proposing how HIV prevention research and development (R&D) for women and girls can better align with programs to improve their health and well-being.

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Research Roundup: the first kid-friendly TB treatment, enlisting smartphones to diagnose malaria, and promising new microbicides

GHTC member TB Alliance announced last week the creation of the first-ever child-friendly tuberculosis (TB) medicines, which are currently undergoing regulatory review by the World Health Organization and should be available in early 2016.

GHTC
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GHTC/Marissa Chmiola
Celebrating US leadership in global health R&D on Capitol Hill

On Wednesday evening, GHTC was joined on Capitol Hill by congressional champions—Congressman Adam Smith (WA-9) and Congresswoman Betty McCollum (MN-4)—and global health community members for a reception celebrating US leadership in global health research and development (R&D) and the launch of the 2015 G-FINDER report, which tracks investment in neglected disease R&D.

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Research Roundup: kid-friendly malaria medicine, Zika fever, priority review vouchers, and more

After four successful Phase 3 clinical trials enrolling more than 3,500 patients in 18 countries, the European Medicines Agency (EMA) has granted Pyramax® Granules, a pediatric malaria medicine, a positive opinion under Article 58—a mechanism through which the EMA reviews and issues a scientific opinion on products that are not intended for use in Europe.

GHTC
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What we’re thankful for in global health

It’s that time of year when Americans chow down on turkey with family and friends and express gratitude for the many things in life for which they are most thankful.

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Research Roundup: Snakebites, TB and parasitic infections, and HIV/AIDS vaccine development

Snakebites, which Médecins Sans Frontières describes as “one of the world's most neglected public health emergencies,” kill 200,000 people each year.

GHTC
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TPP: What does it mean for global health and what’s next?

After ten years of debate, on November 5, 2015, international negotiators released the final text of the largest regional trade agreement in history—the Trans Pacific Partnership (TPP).

GHTC
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Scaling up solutions to save every preemie

Preterm birth complications are the leading cause of death for children under five years of age.

GHTC
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PATH/Eric Becker
Research Roundup: Targeting cattle to fight sleeping sickness, antibodies that protect against distantly related viruses, and more

A new study suggests that the use of anti-parasitic drugs and insecticides in cattle can reduce human cases of Trypanosomiasis (sleeping sickness) by as much as 90 percent.

GHTC
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Research Roundup: tapeworm tumors, a new HIV/AIDS prevention method, and a TB test for low-resource settings

A recently released clinical report from the US Centers for Disease Control and Prevention details a case of a Colombian man who developed cancerous tumors on his lungs and liver that were comprised of tapeworm cells, rather than human cells.

GHTC
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Rapid diagnostics needed to curb antibiotic resistance

New rapid diagnostics are urgently needed to prevent unnecessary use of antibiotics and curb the growing problem of antimicrobial resistance, according to a new report from the United Kingdom’s Review on Antimicrobial Resistance (AMR).

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CDC/Prof Woodridge Foster, Prof. Frank H. Collins
Research Roundup: repurposing ivermectin to fight malaria, LED lights against dengue fever, rapid diagnostics to slow antimicrobial resistance, and more

Findings of a study presented at the American Society of Tropical Medicine and Hygiene Annual Meeting last week suggest that ivermectin—a drug long used to treat river blindness and elephantiasis—can combat malaria when used in mass drug administration programs.

GHTC
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PATH/Jennifer Fox
Germany announces second PDP funding round: What’s different and how does it impact global health R&D

Earlier this month, Germany’s Federal Ministry of Education and Research (BMBF) the renewal of the German funding program for product development partnerships (PDPs) conducting research and development (R&D) for health technologies to combat poverty-related and neglected diseases (PRNDs).

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CDC/National Institute of Allergy and Infectious Diseases
Research Roundup: an aerosol TB vaccine, a new coating for HIV/AIDS drugs, drug-resistant malaria, and more

Researchers at Tulane University successfully tested an experimental aerosol tuberculosis (TB) vaccine in monkeys, demonstrating that the candidate was more effective in protecting against infection than BCG—the only TB vaccine on the market.

GHTC
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GHTC
GHTC briefing highlights importance of health innovation to achieving global goals

With the Sustainable Development Goals (SDGs) freshly adopted, the Global Health Technologies Coalition (GHTC) gathered representatives from the private, public, and nonprofit sectors on Capitol Hill this past Wednesday to discuss what it will take to achieve the global goals.

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The R&D agenda and how it addresses access to vaccines

In this guest post, Dr. Jayasree K. Iyer—Chief Scientific Officer at the Access to Medicine Foundation—writes about the findings from their newest study, which examines the current state of the vaccine pipeline and how large pharmaceutical companies are considering access to these products.

Access to Medicine Foundation
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CDC/Dr. Scott Smith
Research Roundup: an HIV/AIDS vaccine candidate, inflatable incubator for premature babies, and US government R&D

Dr. Robert Gallo co-discovered the HIV virus and subsequently led the development of the first HIV/AIDS blood test.

GHTC
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Tackling hidden hunger through innovation

When most people think of hunger, they think of a lack of food—a nation suffering from crop failure and famine, or a family that can’t afford to put enough food on the table.

GHTC
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CDC
Research Roundup: TB R&D, malaria in pregnancy, and treatments for filarial diseases

A new briefing paper from the Infectious Diseases Society of America Center for Global Health Policy explores the state of tuberculosis (TB) research and development (R&D) including challenges for products currently in the pipeline and gaps in TB research.

GHTC
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Why we need research to detect, prevent, and ultimately, eliminate parasitic diseases

In this guest post, Dr. Monica Parise—deputy director for program and science—and Dr. Larry Slutsker—director of the Division of Parasitic Disease and Malaria—at the US Centers for Disease Control and Prevention (CDC) Center for Global Health—discuss the role of research in advancing efforts to detect, prevent, and eliminate parasitic diseases.

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