Breakthroughs Blog

Breakthroughs brings you stories of bright ideas and bold innovations in global health.

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Jamie Bay Nishi, MA
G20 leaders commit to advance global health, with partial recognition of R&D’s role

On Saturday, heads of state and government from the world’s leading economies concluded this year’s G20 Summit in Osaka, Japan by issuing a declaration committing to advance global health.

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Research Roundup: MERS vaccine for camels, lessons learned from Ebola R&D, and more

A new vaccine against Middle East Respiratory Syndrome (MERS) could save human lives by boosting immunity in camels. MERS, a virus that causes an innocuous cold in camels but kills nearly one-third of human patients, is primarily found in the Arabian Peninsula, where camels are common and 12 percent are infected at any given time.

GHTC
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365 review: Top global health innovation news of 2015

As 2015 draws to a close, the Global Health Technologies Coalition is reflecting on the past year in global health innovation.

GHTC
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Research Roundup: flesh-eating bacteria treatment, Hepatitis C in Egypt, and access to compounds for drug discovery

Global Health Now took an in-depth look at the flesh-eating fungus mycetoma—which enters the body through cuts, and can result in swollen, deformed limbs—in a three-part series on this Untold Global Health Story of 2015.

GHTC
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PATH/Patrick McKern
Global Health Innovation Act has passed the House of Representatives

Last month, Representatives Albio Sires (D-NJ) and Mario Diaz-Balart (R-FL) introduced a new piece of legislation—the Global Health Innovation Act (H.R. 2241)—that would strengthen global health research and development (R&D) programming at the US Agency for International Development (USAID).

GHTC
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TB Alliance
Fruit-flavored drugs to saves kids’ lives: First correctly-dosed, child-friendly TB treatments developed

Early this month, GHTC member TB Alliance and its partners announced the creation of the first-ever appropriate, child-friendly tuberculosis (TB) medicine in the correct doses.

TB Alliance
TB Alliance
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A second chance for a TB research movement

In this guest post, Mike Frick, TB/HIV project officer at the Treatment Action Group (TAG), reflects on activist calls for greater investment in tuberculosis (TB) research and development (R&D) at the 46th Union World Conference on Lung Health and the stagnation of global TB R&D funding at a time of growing drug resistance.

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Research Roundup: Preterm birth indicators, African sleeping sickness treatment, and the world’s first dengue vaccine

Virginia Commonwealth University (VCU) received a grant from the Global Alliance to Prevent Prematurity and Stillbirth, a member of the GHTC, to study the human microbiome in search of biomarkers to predict preterm birth.

GHTC
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Transforming the lives of women and girls in sub-Saharan Africa and helping end AIDS through better HIV prevention research and development

In this guest post Tom Harmon, senior policy analyst at the International AIDS Vaccine Initiative (IAVI), and Anna Forbes, a globally recognized advocate for women’s HIV prevention needs, discuss a new piece proposing how HIV prevention research and development (R&D) for women and girls can better align with programs to improve their health and well-being.

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Research Roundup: the first kid-friendly TB treatment, enlisting smartphones to diagnose malaria, and promising new microbicides

GHTC member TB Alliance announced last week the creation of the first-ever child-friendly tuberculosis (TB) medicines, which are currently undergoing regulatory review by the World Health Organization and should be available in early 2016.

GHTC
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GHTC/Marissa Chmiola
Celebrating US leadership in global health R&D on Capitol Hill

On Wednesday evening, GHTC was joined on Capitol Hill by congressional champions—Congressman Adam Smith (WA-9) and Congresswoman Betty McCollum (MN-4)—and global health community members for a reception celebrating US leadership in global health research and development (R&D) and the launch of the 2015 G-FINDER report, which tracks investment in neglected disease R&D.

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Research Roundup: kid-friendly malaria medicine, Zika fever, priority review vouchers, and more

After four successful Phase 3 clinical trials enrolling more than 3,500 patients in 18 countries, the European Medicines Agency (EMA) has granted Pyramax® Granules, a pediatric malaria medicine, a positive opinion under Article 58—a mechanism through which the EMA reviews and issues a scientific opinion on products that are not intended for use in Europe.

GHTC
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What we’re thankful for in global health

It’s that time of year when Americans chow down on turkey with family and friends and express gratitude for the many things in life for which they are most thankful.

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Research Roundup: Snakebites, TB and parasitic infections, and HIV/AIDS vaccine development

Snakebites, which Médecins Sans Frontières describes as “one of the world's most neglected public health emergencies,” kill 200,000 people each year.

GHTC
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TPP: What does it mean for global health and what’s next?

After ten years of debate, on November 5, 2015, international negotiators released the final text of the largest regional trade agreement in history—the Trans Pacific Partnership (TPP).

GHTC
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Scaling up solutions to save every preemie

Preterm birth complications are the leading cause of death for children under five years of age.

GHTC
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PATH/Eric Becker
Research Roundup: Targeting cattle to fight sleeping sickness, antibodies that protect against distantly related viruses, and more

A new study suggests that the use of anti-parasitic drugs and insecticides in cattle can reduce human cases of Trypanosomiasis (sleeping sickness) by as much as 90 percent.

GHTC
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Research Roundup: tapeworm tumors, a new HIV/AIDS prevention method, and a TB test for low-resource settings

A recently released clinical report from the US Centers for Disease Control and Prevention details a case of a Colombian man who developed cancerous tumors on his lungs and liver that were comprised of tapeworm cells, rather than human cells.

GHTC
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Rapid diagnostics needed to curb antibiotic resistance

New rapid diagnostics are urgently needed to prevent unnecessary use of antibiotics and curb the growing problem of antimicrobial resistance, according to a new report from the United Kingdom’s Review on Antimicrobial Resistance (AMR).

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CDC/Prof Woodridge Foster, Prof. Frank H. Collins
Research Roundup: repurposing ivermectin to fight malaria, LED lights against dengue fever, rapid diagnostics to slow antimicrobial resistance, and more

Findings of a study presented at the American Society of Tropical Medicine and Hygiene Annual Meeting last week suggest that ivermectin—a drug long used to treat river blindness and elephantiasis—can combat malaria when used in mass drug administration programs.

GHTC
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PATH/Jennifer Fox
Germany announces second PDP funding round: What’s different and how does it impact global health R&D

Earlier this month, Germany’s Federal Ministry of Education and Research (BMBF) the renewal of the German funding program for product development partnerships (PDPs) conducting research and development (R&D) for health technologies to combat poverty-related and neglected diseases (PRNDs).

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