Research and development resources

The following reports, fact sheets, and articles from the global health community provide further insight into global health research and development.

Research and development

From Research to Reality: Investing in HIV Prevention Research in a Challenging Landscape

This report show that steady progress in research and development for HIV vaccines, pre-exposure prophylaxis using antiretroviral drugs (PrEP), and treatment as prevention have confirmed the critical role science has to play in providing solutions to end the AIDS epidemic, yet the ninth annual report from the HIV Vaccines and Microbicides Resource Tracking Working Group shows that funding has essentially plateaued.

Authors: AVAC, IAVI, UNAIDS

Publication date: July 2013

Public-private partnerships for global health: How PATH advances technologies through cross-sector collaboration

For more than 30 years, PATH has been working to advance innovative global health solutions. Its goal is to develop and deliver high-impact, cost-effective technologies, including vaccines, drugs, diagnostics, and devices to improve public health.

Author: PATH

Publication date: March 2013

PFG Briefing Papers

The Product Development Partnerships Funders Group (PFG)-- a group based in the UK -- was set up by a number of public and private organizations providing financial support to one or more of the developing health technologies for preventing, diagnosing, or treating diseases of poverty. The PFG released three papers describing collaborations between product development partnerships (PDPs), collaborations between PDPs and pharmaceutical companies, and collaborations between PDPs and pharmaceutical biotechnology companies based in emerging and developing countries.”

Author: PFG

Publication date: November 2012

India’s Role in Global Health R&D

India has already done much to further access to medicines throughout the developing world by producing low-cost generic drugs and follow-on vaccines. As its economy grows and government and industry invest in innovation, many hope India can now contribute in a new way, by developing badly needed new and adapted vaccines, drugs and diagnostics for diseases of the poor. But what is India’s current capacity for new health technology development and how is this capacity likely to evolve? Do the government’s policies support innovation that is important to public health? And as Indian firms gain access to markets in the US and Europe, will they still invest in products for neglected infectious diseases? The Center’s report, “India’s Role in Global Health R&D”, sets out to answer these questions.

Author: Results for Development Institute

Publication date: August 2012

Investing to End the AIDS Epidemic: A New Era for HIV Prevention Research & Development

The most recent report was released at the XIX International AIDS Society Conference in Washington, DC. This report covers investments through 2011 in HIV therapeutic and prophylactic vaccines, microbicides, adult male circumcision, the female condom, PrEP, HSV-2 prevention, prevention of vertical transmission, cure research and treatment as prevention.

Author: HIV Vaccine & Microbicides Resource Tracking Working Group

Publication date: July 2012

HIV Prevention Research and Development Database (PxRD)

PxRD was developed to be a comprehensive source of information on biomedical HIV prevetion clinical trials that are planned, ongoing, or completed. The database enables users to view the clinical trials around the world, gaining an understanding of the many developments currently being made in the field of HIV prevention research.

Author: AVAC

Publication date: June 2012

Accelerating Innovation in the Bioscience Revolution

In an effort to jump-start the discussion of scientific progress, the Milken Institute has releases this report which recaps a discussion among more than 65 leaders in medicine, business, and government who pledged to rethink how research is conducted, how risks are assessed, and how companies are structured.

Author: Milken Institute

Publication date: April 2012

Creating the tools for tomorrow: Investing in global health R&D

This fact sheet examines the advances in global health tools over the years, as well as the need for new and innovative partnerships, and increased investment in global health research and development.

Author: Global Health Technologies Coalition, Bill & Melinda Gates Foundation, Policy Cures, and DSW

Publication date: May 2012

Innovating to improve health

This factsheet describes 10 case studies that discuss the unique ways PATH uses innovation to accelerate the development and delivery of much-needed technologies for low-resource settings. From incubating ideas in a lab to ensuring that a vaccine reaches a child, PATH identifies and overcomes barriers so that the promise of new, effective interventions becomes a life-changing reality for those in need.

Author: PATH

Publication date: April 2012

DONOR tracker

This platform provides objective, comparative policy and budget information on the eight largest European donors: UK, Germany, France, the European Union institutions, Spain, Netherlands, Sweden and Norway. The policy tracker reports on these donors’ global development policy discussions, decisions, and legislation, giving an almost “real time” picture of events via a budget and decision tracker. Each country profile has a section on research.

Author: SEEK development

Publication date: Spring 2012

Treatment as Prevention

This fact sheet describes the basic facts of treatment as prevention, an emerging HIV prevention strategy.

Author: AVAC

Publication date: January 2012

Partnering to Advance Global Health: Advantages of the Product Development Partnership Model

This fact sheet describes the basic components of a product development partnership and how IPM works with its partners to create live-saving technologies.

Author: International Partnership for Microbicides

Publication date: October 2011

Product Development Partnership Infographic

This infographic from Research!America highlights the unique strengths of a Product Development Partnership (PDP) relationship by illustrating two different PDP research and development pipelines.

Author: Research!America

Publication date: October 2011

Georgia and economic impact of global health research and development

This factsheet from Research!America examines the impact that domestic global health research has on the Georgia economy.

Author: Research!America

Publication date: August 2011

Staying the Course? Malaria Research and Development in a Time of Economic Uncertainty (2.74 MB PDF)

This analysis of progress in the global fight against malaria has found a four-fold increase in annual funding for malaria research and development (R&D) in just 16 years—from $121 million in 1993 to $612 million in 2009, with a particularly rapid increase since 2004. The funding has generated the largest-ever pipeline of malaria control and prevention products, including new drugs, vaccines, insecticides, and diagnostics.

Author: Policy Cures

Publication date: June 2011

PrEP Primer

This primer provides an introduction to oral pre-exposure prophylaxis (PrEP) research for HIV prevention, including basic information on PrEP strategies being studied, the scientific rationale for PrEP, the state of the research, who is involved in PrEP, what additionalresearch may be needed, recent research results and ongoing trials.

Author: AVAC

Publication date: February 2011

The U.S. Commitment to Global Health R&D (630 KB PDF)

This factsheet published by Research!America outlines the current US commitment to global health research and development (R&D) for new tools and technologies and shows the impact of US investment in global health R&D.

Author: Research!America

Publication date: February 2011

malERA: A research agenda for malaria eradication

This report aims to identify key knowledge gaps and define the strategies and tools that will result in reducing the basic reproduction rate to less than 1, with the ultimate aim of eradication of the parasite from the human population. Sustained commitment from local communities, civil society, policy leaders, and the scientific community, together with a massive effort to build a strong base of researchers from the endemic areas will be critical factors in the success of this new agenda.

Author: PLoS

Publication date: January 2011

Making Evidence Work for Communities:The Role of Nongovernmental Organizations in Translating Science to Programs (133 KB PDF)

This article published in the Journal of Women's Health explores the unique position that nongovernmental organizations (NGOs) have in implementing evidence-informed public health solutions and fostering research to develop new appropriate interventions and solutions.

Authors: Jennifer Kidwell Drake, M.P.H., Jane E. Hutchings, M.P.H.,and Christopher J. Elias, M.D., M.P.H.

Publication date: November 11, 2010

Accelerating the development of an AIDS vaccine: A U.S. policy agenda (1.18 MB PDF)

This fact sheet from the International AIDS Vaccine Initiative (IAVI) explores key US policy priorities for AIDS vaccine development. The fact sheet also offers concrete suggestions for policy changes to ensure AIDS vaccine development can continue and flourish.

Author: IAVI

Publication date: November 2010

Why is research essential to stop TB? (1.78 MB PDF)

This fact sheet from the Stop TB Partnership highlights how research plays a critical role in eliminating tuberculosis (TB) worldwide. The fact sheet explores the different types of research and their significant impact on reducing the global disease burden of TB and explains how much funding there currently is for research and development and how much is needed in the future.

Author: Stop TB Partnership

Publication date: November 2010

Innovative Product Development Partnerships

This policy brief highlights the characteristics and key accomplishments of product development partnerships (PDPs), nonprofit organizations working to fill gaps in the research and development pipeline for drugs, vaccines, microbicides, and diagnostics against diseases of the developing world. The International AIDS Vaccine Initiative developed this brief in collaboration with the Aeras Global TB Vaccine Foundation, the Drugs for Neglected Diseases Initiative, the Foundation for Innovative Diagnostics, the Global Alliance for TB Drug Development, the International Partnership for Microbicides, the Medicines for Malaria Venture, and PATH.

Author: International AIDS Vaccine Initiative

Publication date: September 2010

Research and the Millennium Development Goals (203.32 KB PDF)

This fact sheet from the Global Health Technologies Coalition examines how research for new global health tools can help achieve the Millennium Development Goals.

Author: Global Health Technologies Coalition

Publication date: September 2010

Leveraging research in foreign assistance (128.9 KB PDF)

This fact sheet from the Global Health Technologies Coalition examines the role of innovation in international development and makes recommendations to elevate global health research in the foreign aid reform process.

Authors: Global Health Technologies Coalition

Publication date: July 2010

Asking the right questions: Advancing an HIV research agenda for women and children (1.42 MB PDF)

This document, a consensus statement from 16 leading public- and private-sector organizations working on HIV/AIDS, provides 20 specific recommendations to improve access to to effective HIV prevention, treatment, and care for women and children.

Authors: International AIDS Society; amFAR; AIDS Vaccine Advocacy Coalition; Boehringer Ingelheim; Clinton Health Access Initiative; Coalition on Children Affected by AIDS; Elizabeth Glaser Pediatric AIDS Foundation; European AIDS Treatment Group; International Community of Women Living with HIV/AIDS; International Treatment Preparedness Coalition; Merck & Co.; Treatment Action Group; UNAIDS; UNICEF; ViiV Healthcare; World Health Organization.

Publication date: March 2010

Beating the brain drain: West African research centre shows it can be done (website)

This June 2009 article on the website TropIKA.net describes the Malaria Research Training Centre’s attempts to attract and retain African scientists studying malaria.

Innovation in action: Policies to accelerate the development and delivery of global health tools (1.56 MB PDF)

The first annual report of the Global Health Technologies Coalition (GHTC) focuses on the GHTC's three priority areas—US policies related to public financing, regulatory pathways, and incentives and innovating financing. It highlights the role US agencies and policymakers play in advancing innovation for global health products, as well as makes policy recommendations to help accelerate the development of new global health technologies.

Authors: Global Health Technologies Coalition

Publication date: April 2010

Investing in vaccines for the developing world (website)

This fact sheet, accessed from the PATH website, details the cost of developing and distributing vaccines and outlines innovative funding solutions designed to address these issues.

Medical research: What’s it worth? Estimating the economic benefits from medical research in the UK (2.0 KB PDF)

This report arises from an effort to compile a quantative assessment of the benefit of medical research to the United Kingdom by comparing the macroeconomic benefits accruing from medical research with the cost of that research. 

Authors: Health Economics Group, Brunel University; Office of Health Economics: RAND Europe

Publication date: November 2008

Neglected disease pipeline (website)

This website from BIO Ventures for Global Health features information on 16 neglected diseases of the developing world. The site gives background information on each disease, including existing tools like vaccines and drugs, the medicines that are still needed, potential markets, and the current product pipeline.

Policies and practices to advance global health technologies: A report of the CSIS Global Health Policy Center (673 KB PDF)

This report presents arguments for supporting research and development in global health technologies and includes policy recommendations to help ensure that the United States remains a leader in the field.

Author: Dr. Christopher J. Elias, Center for Strategic & International Studies

Publication date: April 2009

Spurring Innovation in AIDS Vaccine R&D: What Will it Take? (1,327 KB PDF)

This policy brief from the International AIDS Vaccine Initiative explores a variety of mechanisms seeking to generate solutions to global health problems, including the need for new HIV and AIDS technologies. It includes recommendations on how to move forward in creating an appropriate enabling environment for innovative ideas and approaches.

Author: International AIDS Vaccine Initiative

Publication Date: April 2009

The US commitment to global health: Recommendations for the public and private sectors (2.13 KB PDF)

This book outlines the commitment of the US government, nongovernmental organizations, universities, foundations, and commercial entities to global health, including suggestions for actions to accelerate progress on improving global health.

Authors: Committee on the US Commitment to Global Health; Institute of Medicine of the National Academies

Publication date: 2009

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