Incentives and innovative financing resources

The following reports, websites and fact sheets provide further details about incentives and innovative financing mechanisms. Resources are listed alphabetically within each subcategory.

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Incentives and innovative financing

Innovative Financing for Global Health R&D

This report, with support from the Bill & Melinda Gates Foundation, convened a Financial Innovations Lab® to map current and potential models with the goal of leveraging traditional sources of aid to attract private-sector investment and increase sustainable funding for R&D.

Author: Milken Institute

Publication date: November 2012

World Economic and Social Survey 2012: In Search of New Development Finance (website)

The World Economic and Social Survey 2012 analyses current and proposed mechanisms for innovative development finance and highlights mechanisms that can 1) increase the scale of development financing available and 2) provide stable and predictable financing to enhance sustainable development.

Author: UN Development Policy and Analysis Division

Publication date: August 2012

Innovative Financing Mechanisms for Global Health: Overview & Considerations for US Government Participation (1.15 MB PDF)

This report from the Kaiser Family Foundation examines new financing mechanisms for global health and assesses the role of the U.S. government for engaging in these financing mechanisms as part of its global health effort.

Author: Kaiser Family Foundation

Publication date: October 2011

Prizes for Global Health Technologies

This report offers a general framework for assessing prizes for global health and a detailed analysis of prize proposals for new diagnostic tests for tuberculosis.

Author: Results for Development Institute

Publication date: 2011

Incentives and innovative financing for global health product development (508 KB PDF)

This fact sheet from the Global Health Technologies Coalition explores different incentives and innovative financing mechanisms and their role in global health product development.

Author: Global Health Technologies Coalition

Publication date: October 2010

Engaging the Debates: An Update on Innovative Financing Mechanisms for Global Health

This policy brief supplement examines innovative financing mechanisms that could help sustain and increase funding for research and development of new biomedical products for the developing world, including an Advance Market Commitment, financial transaction taxes, and the MASSIVEGOOD program.

Author: International AIDS Vaccine Initiative

Publication date: September 2010

Assistance for neglected diseases: A time for partnership (19 KB PDF)

This report outlines work led by the Genzyme Corporation to bring together a diverse range of groups to develop practical and innovative polices for the dissemination of breakthrough treatments for people with neglected diseases.

Current and proposed incentive mechanisms: GHTC Incentives & Innovative Financing Working Group (48 KB PDF)

This report explains existing and proposed incentive mechanisms to encourage health technologies research and development either being used by the Global Health Technologies Coalition or under consideration by the group.

Author: Global Health Technologies Coalition

Glossary of financing terms (website)

This website from the GAVI Alliance includes a glossary of public health and financing terms.

Improving health R&D financing for developing countries: A menu of innovative policy options (1.70 KB PDF)

This paper in the journal Health Affairs summarizes some of the most promising new ideas for financing the development of new health technologies.

Authors: Robert Hecht, Paul Wilson, and Amrita Palriwala

Publication date: July 2009

Innovative Financing for Global Health: A Moment for Expanded U.S. Engagement? (729 KB PDF)

This report from the Center for Strategic and International Studies Commission on Smart Global Health Policy evaluates the promise of innovative financing and incentive mechanisms for global health, including advance market commitments, and explores the potential for future US engagement.

Authors: Robert Hecht, Amrita Palriwala, and Aarthi Rao

Publication date: March 2010

Innovative financing for global health: Tools for analyzing the options (4.58 KB PDF)

This report from the Brookings Global Economy and Development working paper series arises from a study whose goal was to help decision-makers facing choices about innovative financing mechanisms for global health.

Authors: David de Ferranti, Charles Griffin, Maria Luisa Escobar, Amanda Glassman, Gina Lagomarsino 

Publication date: August 2008

Innovative Financing Mechanisms to Advance Global Health (5,973 KB PDF)

This policy brief from the International AIDS Vaccine Initiative reviews recent innovations in health financing and new options under consideration to address current funding gaps that deter efforts to improve health in resource-limited countries.

Author: IAVI

Publication Date: June 2009

Making drugs accessible to poor populations : A funding model (886 KB PDF)

This article in Global Forum Update on Research for Health discusses the use of a fund for research and development in neglected diseases to support development of therapies for neglected diseases and to make resulting therapies available to poor patients in the developing world.

Author: Paul L. Herrling

Push and pull (website)

Economist James Surowiecki describes how push and pull mechanisms work in this 2004 article from The New Yorker magazine.

Research and Development Coordination and Financing (3,238 KB PDF)

The final report of the WHO Expert Working Group on Research and Development Financing examines current financing and coordination of research and development, and proposals for new and innovative sources of financing to stimulate research and development

Publication date: 2010

Pull mechanisms

Pneumococcal AMC process & design evaluation (website)

A new evaluation of the pilot Advance Market Commitment (AMC) for pneumococcal vaccines examines the innovative funding mechanism, which has already helped vaccinate 13 million children against pneumonia—the world’s biggest childhood killer.

Author: Dalberg Global Development Advisors

Publications date: March 2013

The Impact of the US Priority Review Voucher on Private-Sector Investment in Global Health Research and Development (website)

This study looks for closely at market incentives that play an important role in mobilizing companies toward neglected tropical disease research.

Author: BIO Ventures for Global Health

Publications date: August 2012

Exploring the role of the US Government in a future advance market commitment (258 KB PDF)

This fact sheet from the Global Health Technologies Coalition provides specific recommendations to US policymakers about the role and engagement of the US Government in a future advance market commitment.

Author: Global Health Technologies Coalition

Publication Date: March 2011

S. 3697 Priority review voucher (PRV) legislation (603.25 KB PDF)

Legislation to amend the Federal Food, Drug, and Cosmetic Act to improve the priority review voucher incentive program relating to tropical and rare pediatric diseases.

Advance market commitments (website)

This website, a project of the GAVI Alliance and World Bank Group, provides news and information on the use of advance market commitments to develop vaccines.

Advance market commitments: Frequently asked questions (245 KB PDF)

A fact sheet from the GAVI Alliance that answers questions often asked about advance market commitments.

Author: GAVI Alliance

An AMC for pneumococcal diseases: Frequently asked questions (151 KB PDF)

A fact sheet from the GAVI Alliance that answers questions about pilot projects using advance market commitments to speed development and distribution of vaccines for pneumococcal diseases.

Author: GAVI Alliance

Drug development for neglected diseases—the trouble with FDA review vouchers (93 KB PDF)

This perspective article in the New England Journal of Medicine discusses the drawbacks of a US government program intended to promote the development of pharmaceutical products for neglected diseases.

Author: Aaron S. Kesselheim

Publication date: November 2008

Glaxo to share vaccine technology with Brazil (website, subscription required)

This September 2009 article from the Wall Street Journal covers GlaxoSmithKline PLC’s decision to give Brazil some of its vaccine technology and fund research on vaccine for dengue fever. Requires website subscription.

GAVI Alliance (website)

The website of the GAVI Alliance is a comprehensive look at the ongoing work of this organization dedicated to increasing access to immunization in poor countries.

International AIDS Vaccine Initiative Challenge on InnoCentive (website)

This posting on the InnoCentive blog showcases an interview with the director of New Alliances & Initiatives at the International AIDS Vaccine Initiative and outlines the initiative’s challenge, calling for help in creating a vaccine against HIV/AIDS.

Making markets for vaccines: Ideas to action (1.76 KB PDF)

This report from the Center for Global Development shows how advance market commitments can work within ordinary legal and budgetary principles, and includes a draft contract term sheet.

Author: The Center for Global Development Advance Market Commitment Working Group

Publication date: 2005

Preventing pneumococcal diseases: An advance market commitment for new vaccines (179 KB PDF)

This factsheet from the GAVI Alliance addresses how advance market commitments were used in pilot projects to speed the process of making improved vaccines against pneumococcal diseases available in developing countries.

Priority review vouchers: fact sheet (134 KB PDF)

This factsheet explains the Food and Drug Administration’s program aimed at encouraging investment in new drugs and vaccines to treat neglected tropical diseases.

Author: BIO Ventures for Global Health

Publication date: 2008

Public law 110-293 (279 KB PDF)

This document provides text of a July 2008 authorization from congress that provides assistance to foreign countries to fight HIV and AIDS, tuberculosis, and malaria.

Push mechanisms

Pooled resources to advance global health R&D: Understanding pooled funding mechanisms and the implications for global health prodcut development

This webinar discusses pooled funding mechanisms as a resource to support and advance global health R&D and offers mutliple perspectives on the topic.

Host: Global Health Technologies Coalition

Publication date: December 2014

An assessment of the SBIR program

This book-length report from the National Academy of Sciences arises from a National Research Council study of how the Small Business Innovation Research Program has worked to encourage technological innovation and has helped small businesses meet US government research and development goals.

Author: Charles W. Wessner, editor

Publication date: 2008

Can patients deter innovation? The anticommons in biomedical research (website)

This online article in a May 1998 edition of Science argues for the careful deployment of privatized biomedical research.

Authors: Michael Heller and Rebecca Eisenberg

Currency transaction tax (website)

This online report from the Leading Group on Innovative Financing for Development explains the ideas behind using a currency transaction tax to finance global public health goods.

Discussion draft of a bill to amend the Internal Revenue Code (53 KB PDF)

Text of a discussion draft of a bill for the US House of Representatives that would amend the tax code to provide a tax credit for expenses incurred in nonclinical research for neglected diseases.

Publication date: March 2007

Neglected disease tax credit (93 KB PDF)

This one-page fact sheet describes the Neglected Disease Tax Credit proposal, which is designed to encourage companies to develop treatments for neglected diseases.

SBIR/STTR Reauthorization Act of 2008 (120 KB PDF)

Text of a US Senate bill reauthorizing the Small Business Innovation Research Program and Small Business Technology Transfer Program.
Publication date: August 2008


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